Outcomes

The project’s outcomes include scientific publications, conference presentations, and patent applications, reflecting its contributions to research, innovation, and knowledge dissemination.

Papers

  • "Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment" - Magnetic Resonance in Medicine - 2025 - http://doi.org/10.1002/mrm.70193
    Fenech P., Morelli L., Parrella G., Imparato S., Iannalfi A., Lillo S., Orlandi E., Baroni G., Paganelli C.

    This study evaluates quantitative susceptibility mapping (QSM) beyond the brain through realistic simulations and explores preliminary evidence that may be indicative of hypoxia in skull base chordomas (SBC).

  • "Microstructural modelling based on diffusion weighted imaging to guide dose painting in carbon ions for large sacral chordomas" - Physics and Imaging in Radiation Oncology, Volume 36 - 2025 - https://doi.org/10.1016/j.phro.2025.100887
    Parrella G., Morelli L., Magro G., Glimelius L., Ödén J., Ciocca M., Imparato S., Rotondi M., Fiore M.R., Orlandi E., Baroni G., Molinelli S., Paganelli C.

    This study investigates the use of advanced microstructural modelling from conventional diffusion-weighted imaging to enable dose painting in carbon ion radiotherapy. The approach allows increasing tumor control probability while ensuring organ sparing.

  • "Microstructural profiling and habitat analysis to characterize treatment outcome patterns in sacral chordomas treated with carbon ions" - Medical Physics, Volume 53 - 2025 - https://doi.org/10.1002/mp.70208
    Morelli L., Parrella G., Rotondi M., Molinelli S., Magro G., Imparato S., Chalaszczyk A., Fiore M.R., Paganelli C., Orlandi E., Baroni G.

    This study explores the use of microstructural parameters and habitat analysis from diffusion-weighted MRI (DW-MRI) to characterize intratumoral heterogeneity, monitor treatment-induced changes after carbon ion radiotherapy, and examine their relationship with recurrence patterns in sacral chordoma patients.

  • "Tumor control probability in large sacral chordomas treated with carbon ions radiotherapy integrating advanced microstructural modelling" - Physica Medica, Volume 136 - 2025 - 10.1016/j.ejmp.2025.105038
    Parrella G., Morelli L., Molinelli S., Magro G., Glimelius L., Ödén J., Ciocca M., Imparato S., Rotondi M., Fiore M.R., Orlandi E., Baroni G., Paganelli C.

    This work investigated the integration of DWI-derived cell density into LQ Poisson TCP model for sacral chordomas, enhancing prediction of local control after carbon ion therapy.

Patents

  • "Mappatura multi-scala e personalizzata del microambiente tissutale" - 102025000010722, filed on May 13, 2025
    Paganelli C., Baroni G., Morelli L., Parrella G., Scotti C., Tinelli C., Fenech P.

    The invention relates to a method for multi-scale, personalized mapping of the tissue microenvironment, involving realistic and dynamic in silico 3D cellular substrates, multiparametric MR simulation, patient-specific data comparison, and optionally, radiation-matter interaction modeling.

Conferences

  • "Creating realistic in silico tumour substrates for application in personalised radiation therapy" - RAPTOR Online Adaptive PT Workshop - 2025
    Scotti C., Tinelli C., Fenech P., Baroni G., Morelli L., Paganelli C.
  • "Monte Carlo simulations of radiation – tissue interaction on realistic in silico tumor substrates for application in personalized radiation therapy" - RAPTOR Online Adaptive PT Workshop - 2025
    Tinelli C., Scotti C., Fenech P., Baroni G., Morelli L., Paganelli C.
  • "Quantitative Susceptibility Mapping for skull base chordoma: a step towards personalized particle therapy" - PTCOG 63 - 2025
    Fenech P., Morelli L., Parrella G. , Imparato S., Iannalfi A., Lillo S., Orlandi E., Baroni G., Paganelli C.
  • "Cellularity-guided dose painting in carbon ion radiotherapy for large sacral chordomas to maximize tumor control probability" - PTCOG 63 - 2025
    Parrella G., Morelli L., Lars G., Jakob O., Colomar D.S., Magro G., Chalaszczyk A., Imparato S., Rotondi M, Mario C., Fiore M.R., Orlandi E., Baroni G., Molinelli S., Paganelli C.
  • "Tracking microstructural evolution in local recurrence of Sacral Chordomas treated with carbon ions" - PTCOG 63 - 2025
    Morelli L., Parrella P., Rotondi M., Molinelli S., Imparato S., Chalaszczyk A., Fiore M.R., Paganelli C., Orlandi E., Baroni G.